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# Innophore

Enzyme & Drug Discovery

## Sitemaps

- [XML Sitemap](https://innophore.com/sitemap.xml): Contains all public & indexable URLs for this website.

## Pages

- [Home](https://innophore.com/) - Catalophore™ cavity technology The discovery engine for the molecular world. We map every protein binding site as a searchable hyperdimensional point-cloud fingerprint, so you can find enzymes, drugs and off-targets by what they do, not how they look. The method the press called the Google for enzymes. Explore the technology → Talk to us →
- [Catalophore Tox Station](https://innophore.com/software/catalophore-tox-station/) - Catalophore Tox Station Off-target safety screening, on your desk. An NVIDIA DGX Spark prepared for in silico toxicology. Compare the binding site of your target with the human proteome or with focused panels by target class, from kinases and GPCRs to nuclear receptors and ion channels, and let Catalophore Intelligence interpret every cavity. All computation
- [Catalophore On-Premise](https://innophore.com/software/catalophore-on-premise/) - On-Premise Desktop System The Catalophore platform, running on your desk. An NVIDIA DGX Spark, delivered with Catalophore Platform Pro, Catalophore Studio, LigForge and Catalophore Intelligence installed and ready to use. Target discovery, off-target validation, enzyme discovery and generative ligand design run on the system itself, AI features included. Connect by WiFi, office network or screen
- [Publications](https://innophore.com/technology/publications/) - Publications & Case Studies All Brochure Publication Blog Post Poster Case Study Innophore’s Company Brochure Learn about our technology, the way we work, and the success stories behind our latest case studies. Ligand-agnostic off-target site prediction for early toxicity screening by leveraging point cloud-based protein cavity analysis Parigger, L., Takai, T., Hetmann, M. et al.
- [Team](https://innophore.com/company/team/) - LinkedIn LinkedIn LinkedIn LinkedIn LinkedIn LinkedIn LinkedIn LinkedIn LinkedIn LinkedIn LinkedIn LinkedIn LinkedIn LinkedIn LinkedIn LinkedIn Collective Expertise The skills in the room. A snapshot of what our team works in, every day. Computation & AI Structural bioinformatics 3D point clouds Protein structure prediction AlphaFold 2 · ESMFold · OpenFold Deep learning Computer vision Molecular
- [Catalophore Platform Pro](https://innophore.com/software/catalophore-platform-pro/) - The Molecular Intelligence Platform Your whole protein library, one searchable workbench. Catalophore Pro brings every structure, sequence, cavity, ligand and experiment into one place, then lets you search millions of binding sites by shape and physico-chemical property, run modelling and docking on your own compute or in the cloud, your choice, and hand the results
- [for Biotechnology](https://innophore.com/services/for-biotechnology/) - Service. For Biotechnology. An enzyme that works at your conditions, not in a model organism. Innophore designs and engineers enzymes for industrial biotech across flavor and fragrance, consumer goods, food, biomaterials, biosensors, biofuels, environmental and diagnostics. Cavity-first computational discovery, structure-guided engineering for activity, selectivity and stability, and partner wet-lab follow-up when needed. Customer keeps the
- [Case study — Cryo-EM mechanism of diazaborine inhibition of Drg1](https://innophore.com/case-drg1-cryoem/) - Case study · Structural biology · Cryo-EM How a known drug actually kills its target. First high-resolution cryo-EM structure of the hexameric AAA-ATPase Drg1, in complex with the inhibitor diazaborine. The structure shows a striking, previously unknown mechanism: the drug forms a covalent bond to the 2′-OH of the bound nucleotide in the D2 domain
- [Case study — AI-assisted structural consensus proteome of monkeypox virus](https://innophore.com/case-mpox-proteome/) - Case study · Outbreak response · Monkeypox An average structural proteome of the currently circulating monkeypox virus. An early-outbreak response: 3,713 genome sequences sampled within a year of the 2022 multi-country MPX outbreak, distilled into a consensus structural proteome of 210 proteins, each modelled three ways and screened for mutations at the binding sites of
- [Case study — Folding the human proteome with NVIDIA BioNeMo](https://innophore.com/case-human-proteome/) - Case study · Reference dataset · Joint with NVIDIA Folding the human proteome with NVIDIA BioNeMo. A jointly built reference dataset of 42,042 structural models for 99.72 % of the protein-level confirmed human reference proteome — combining AlphaFold 2, OpenFold and ESMFold from NVIDIA’s BioNeMo platform with Innophore’s CavitomiX homology pipeline, published openly in Scientific
- [Case study — CavitOmiX Drug Discovery for arboviral diseases](https://innophore.com/case-arbo-cavitomix/) - Case study · Antiviral drug discovery Repurposed antivirals against chikungunya, screened against the human off-target space. Climate change is bringing arboviral diseases to new latitudes. There is no approved drug for chikungunya, dengue or zika. We used CavitOmiX™ point-cloud cavity matching to scan approved drugs against the ADP-ribose binding site of CHIKV nsP3, ranked candidates
- [Case study — Species-selective inhibition of a TB lipase, guided by cavity comparison](https://innophore.com/case-rv0183-tb/) - Case study · Anti-tuberculosis Species-selective inhibition of a TB lipase, guided by cavity comparison. High-throughput screening at the European Lead Factory funnelled 469,468 compounds down to a handful of Rv0183 inhibitors. Catalophore™ point-cloud cavity analysis then showed where the M. tuberculosis lipase differs from its human cousin — opening a door to inhibitors that hit
- [Case study — Broad-scope IRED library at equimolar conditions](https://innophore.com/case-ired-roche/) - Case study · Reductive amination Asymmetric reductive amination at equimolar substrate concentrations. Most reductive amination screens need a large excess of amine to work, and rarely deliver high stereoselectivity at the same time. Together with Genentech, Roche and the University of Graz, we profiled a library of imine reductases and reductive aminases that runs at
- [for Pharma](https://innophore.com/services/for-pharma/) - Service. For Pharma. Hits, repurposed drugs, off-targets. A binding-site-first way to find them. Innophore runs computational programs for global pharma, biotech and CDMOs across discovery, safety and manufacturing. Hit identification by virtual screening against curated pockets. Drug repurposing by cavity-based matching to approved-drug databases. Off-target screening across the human proteome. De novo ligand design with
- [Catalophore Technology](https://innophore.com/technology/catalophore-new/) - Catalophore™ technology We search the molecular world by shape and chemistry. Catalophore describes a binding site as a 3D point cloud and matches it across entire proteomes, so we can find enzymes, drugs and off-targets by what a cavity does, not by sequence or fold. How it works → Read the publications → The principle
- [About us](https://innophore.com/company/about/) - About Innophore The search engine for the molecular world A decade ago, our founders asked a simple question: if you can search the whole web for a phrase, why can't you search all of nature for a function? That question became Innophore. Our Catalophore™ 3D point-cloud technology treats every protein cavity as a searchable fingerprint,
- [for Virology](https://innophore.com/technology/virology/) - For Virology A new virus emerges. We start with its cavities. When a novel pathogen or variant appears, there is a genome long before there are structures, targets or drugs. Innophore's Catalophore™ point-cloud technology maps every binding site across a viral proteome — to repurpose approved drugs, design broad-spectrum antivirals and track variant escape, in
- [Target discovery](https://innophore.com/technology/pharma/) - The Cavity Layer Discovery finds the target. Safety models the body. What happens in between? Innophore's Catalophore™ point-cloud technology is the layer that maps structure-based off-target binding across the entire proteome — connecting molecular discovery with safety and DMPK modeling. Patented, GPU-accelerated, and validated with a global pharma leader. Request a pilot → Explore integration
- [Catalophore Studio](https://innophore.com/software/catalophore-studio/) - The Protein Cavity Workbench See the binding site. Understand it. Design against it. Catalophore Studio turns a raw protein structure into an interpreted binding site in seconds. It unites point-cloud cavity detection, 30+ physicochemical property fields, structure-aware AI reasoning, ligand preparation, docking and proteome-wide cavity search, all in one interactive workbench, powered by Innophore's Catalophore™
- [Software](https://innophore.com/software/) - Software One technology. Four ways to use it. Every Innophore tool runs on the same Catalophore™ point-cloud cavity technology. Pick the one that fits how you work: a full on-premise platform, a desktop workbench, a cloud copilot, or a plugin for the tool you already use. Catalophore Platform Pro The full platform, on your own
- [Services](https://innophore.com/services/) - Services Cavity science, applied to your industry. We run computational discovery and engineering as a service, on the same Catalophore™ point-cloud cavity technology behind our software. Bring a reaction, a target or a sequence. You keep the IP on every enzyme, hit and variant we deliver. for Biotechnology Industrial enzymes, built for your process. Cavity-first
- [Enzyme discovery](https://innophore.com/technology/biotechnology/) - For Biotechnology You know the reaction. Where is the enzyme that runs it? Innophore's Catalophore™ point-cloud technology searches all of protein space by the shape and chemistry of an active site, not by sequence, to find and engineer enzymes that run your reaction under your conditions. The method the press once called the "Google for
- [Media and News](https://innophore.com/company/media/) - News & Media Archive Media News Paper Research Innophore Is Folding the Human Proteome Using NVIDIA BioNeMo, Creating a Fused Dataset of Structural Models for Machine Learning Purposes 8. January 2024 Media News Press clippings from 2020, 2021 and 2022 20. October 2022 Media News Paper Research Media response to our latest publication 28. September
- [Contact](https://innophore.com/company/contact/) - Contact office@innophore.com+43 (0) 316 / 269 205 Linkedin Europe HQ Am Eisernen Tor 38010 Graz, Austria USA HQ 1700 Montgomery StreetSan Francisco, CA 94111, USA Office Austria Leechgasse 58010 Graz, Austria
- [Company](https://innophore.com/company/) - Redirecting to About…
- [Technology and software](https://innophore.com/technology/catalophore/) - Technology & Software Change the way you search It is easy to get lost in the vast amount of bioinformatics information available to us today. A targeted and novel approach is crucial for true discoveries. To more efficiently identify new drug candidates or enzymes, we need to change how we search and go beyond traditional
- [Technology](https://innophore.com/technology/) - Redirecting to Catalophore…
- [CavitOmiX](https://innophore.com/software/cavitomix/) - Get the plugin! The CavitOmiX PyMOL plugin is free, but you can contributed to our development fund. Every contribution helps us to improve the tool and will empower the scientific community. Contribute to our Development Fund Download the PyMol plugin CavitOmiX here How to install the plugin? Read more here: https://pymolwiki.org/index.php/Plugins A PyMol Plugin Cavitomix
- [CavitOmiX_old](https://innophore.com/cavitomix_old/) - Get the plugin! Download the PyMol plugin CavitOmiX here How to install the plugin? Read more here: https://pymolwiki.org/index.php/Plugins A PyMol Plugin Cavitomix is the art and science of making sense of the binding and interaction sites of biomolecules. CavitOmiX plugin for Schrodinger’s PyMOL, a nifty tool that allows you to analyze protein cavities from any
- [Data Protection Declaration](https://innophore.com/data-protection-declaration/) - Data protection declaration Erklärung zur Informationspflicht(Datenschutzerklärung) Internet-DatenschutzerklärungDie Innophore GmbH nimmt den Schutz Ihrer personenbezogenen Daten sehr ernst. Wir verarbeiten personenbezogene Daten, die beim Besuch unserer Webseiten erhoben werden, unter Beachtung der geltenden datenschutzrechtlichen Bestimmungen der EU Datenschutz Grundverordnung (EUDSGVO). Ihre Daten werden von uns weder veröffentlicht noch unberechtigt an Dritte weitergegeben. Im Folgenden erläutern wir,
- [Press Guidelines](https://innophore.com/press-guidelines/) - Innophore / CavitOmiX Press Guidelines Guidelines für Press Releases, Blogs, Logos, und Website Content Wir ermutigen unsere Partner und Kunden, Erfolgsgeschichten und innovative Lösungen hervorzuheben, die durch Innophore-Technologien oder Cavitomix-Produkte ermöglicht werden. Um eine konsistente und korrekte Markenpräsentation zu gewährleisten, müssen alle Materialien, die sich auf Innophore, Cavitomix oder verwandte Technologien beziehen, diesen Richtlinien entsprechen
- [Technology and software_NEW](https://innophore.com/technology-and-software_new/) - Our Technology STOP SEARCHING START FINDING Function over form Navigating the wealth of bioinformatics data requires a targeted, innovative approach. To identify new drug candidates or enzymes efficiently, we must move beyond traditional algorithms and data types. By coupling our patented CatalophoreTM technology to state-of-the-art conventional bioinformatics approaches as well as artificial intelligence, we mine
- [News & Media](https://innophore.com/news-media/) - News & Media Innophore strongly believes that communication between science and the public is essential. Consequently, our team actively promotes such communication, including social media, traditional media, and contributions to European Researchers’ Nights. This helps to make progress and achievements tangible for the general public and to push the fascination and acceptance of science and
- [News & Media archive NEW](https://innophore.com/news-media-archive-new/) - News & Media Archive Innophore News Archive Media News Paper Research Innophore Is Folding the Human Proteome Using NVIDIA BioNeMo, Creating a Fused Dataset of Structural Models for Machine Learning Purposes 8. January 2024 Media News Press clippings from 2020, 2021 and 2022 20. October 2022 Media News Paper Research Media response to our latest
- [News & Media_NEW](https://innophore.com/news-media_new/) - News & Media Innophore strongly believes that communication between science and the public is essential. Consequently, our team actively promotes such communication, including social media, traditional media, and contributions to European Researchers’ Nights. This helps to make progress and achievements tangible for the general public and to push the fascination and acceptance of science and
- [get in touch](https://innophore.com/get-in-touch/) - contact us Markus Fleck Senior Machine Learning Engineer Bettina Nestl COO Christian Gruber CEO informational Material and Links Learn more about our technology and recent case studies in our company brochure. Download our company brochure as a pdf here. When we discuss cavitomix as a field of study, it covers the integrated art and science
- [maintenance](https://innophore.com/maintenance/) - We are currently working on your system! The system will be up again as soon as possible… Try again! Thank you for your patience!
- [privacy policy app](https://innophore.com/privacy-policy/) - CavAR – Augmented catalophore cavity viewer To use our CavAR viewer, Protein promotion CARDS and the app are needed. You can find the “CavAR – Augmented catalophore cavity viewer” in the Google Play Store. If you did not pick up our cards from one of our booths, you can also download them here to print and
- [Poster Gallery](https://innophore.com/poster-gallery/) - Poster Gallery
- [Apps](https://innophore.com/apps/) - CavAR – Augmented catalophore cavity viewer To use our CavAR viewer, Protein promotion CARDS and the app are needed. You can find the “CavAR – Augmented catalophore cavity viewer” in the Google Play Store. If you did not pick up our cards from one of our booths, you can also download them here to print and
- [welcome](https://innophore.com/welcome/)
- [Imprint](https://innophore.com/imprint/) - Imprint Verantwortlich für den Inhalt:Innophore GmbHAm Eisernen Tor 38010 Graz office@innophore.com+43 316 269 205 Informationspflicht nach § 5 Abs. 1 E-Commerce-Gesetz:Firmenname: Innophore GmbHAddresse: Am Eisernen Tor 3Postleitzahl: 8010 GrazTel: +43 (0) 316 / 269 205Homepage: www.innophore.comE-Mail: office@innophore.com Firmenbuchnummer: FN 464141 k(Landesgericht für Zivilrechtssachen Graz)UID: AT U71943613Mitgliedstaat: ATSteuernummer: AT U71943613 Geschäftszweck:B2B-Vertrieb einer Enzymsuchplattform und von Enzyminformationen.Beschreibung
- [General Terms And Conditions](https://innophore.com/agb-general-terms-and-conditions/) - GENERAL TERMS AND CONDITIONS Download General Terms and Conditions ALLGEMEINE GESCHÄFTSBEDINGUNGEN für den Verkauf und die Lieferung von Organisations-, Programmierleistungen und Werknutzungsbewilligungen von Softwareprodukten, sowie von Dienstleistungen im Bereich der strukturellen Bioinformatik (B2B) 1.1, 2018 Die Übersetzung der Paragraphen ins Englische ist nur zur Information beigefügt. Im Falle von Widersprüchen zwischen der englischen und der
- [disabledsystem](https://innophore.com/disabledsystem/) - License Expired Your system is currently disabled Your license has expired and we have not seen you in a while, to save resources we disabled your system for the time being. If you want to have access to your system again please contact the Innophore license team at licenses(at)innophore.com Try again! Thank you for your
- [Covid19](https://innophore.com/covid19/) - SARS-CoV-2 Virus Watch: An AI-based SARS-CoV-2 affinity prediction About Virus Watch: We as Innophore are proud to have teamed up with Amazon Web Services (AWS). The global DDI (Diagnostic Development Initiative) program, which supports SARS-CoV-2 projects worldwide, will provide us with computing power through AWS sevices to develop and handle predictions of upcoming SARS-CoV-2 variants
- [Case Study: Unexpected Enzymatic Activity](https://innophore.com/case-study-unexpected-enzymatic-activity/) - Brows our other case studies Case Study: Unexpected Enzymatic Activity Case Study: Regaining Stability Case Study: Unexpected Enzymatic Activity Case Study: Regaining Stability CASE STUDY | BIOCATALYSIS IN DRUG DEVELOPMENT & MANUFACTURING Unexpected Enzymatic Activity Overall structure and point cloud of search template (left) compared to newly identified enzyme (right). Back in 2014, we developed
- [Case Study: Regaining Stability](https://innophore.com/case-study-regaining-stability/) - Brows our other case studies Case Study: Unexpected Enzymatic Activity Case Study: Regaining Stability Case Study: Unexpected Enzymatic Activity Case Study: Regaining Stability CASE STUDY | BIOCATALYSIS IN DRUG DEVELOPMENT & MANUFACTURING Regaining Stability Plotted 2D data of inter-chain interactions. An imine reductase from Myxococcus stipitatus was engineered for altered cofactor specificity (NADH) and reversed
- [book a meeting](https://innophore.com/book-a-meeting/) - Discover the protein & drug discovery AI platform of the future now and book a meeting! First name Last name Business Email Company/Institute Your message (optional) I'm interested in the following fields: BiotechnologyPharmaPublic HealthOthers [wpcaptcha wpcaptcha-573]
- [disabledsystem_backup_DO NOT DELETE](https://innophore.com/disabledsystem_backup/) - License Expired Your system is currently disabled Your license has expired and we have not seen you in a while, to save resources we disabled your system for the time being. If you want to have access to your system again please contact the Innophore license team at licenses(at)innophore.com Thank you for your support, and
- [Reserch as a Service](https://innophore.com/reserch-as-a-service/) - RaaS Research as a Service STRONGER IN A TEAM Together with our team of scientists you will identify new or novel enzyme candidates for your reaction or process based on structural features of active sites. For the identification of these enzymes we are using in-silico methods applying our Catalophore platform, a combination of prepared structural
- [Sankey](https://innophore.com/sankey/) - CONTACT

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## Media Hub

- [Austrian Broadcasting Corporation 24.02.2021](https://innophore.com/media/austrian-broadcasting-corporation-24-02-2021/)
- [Galileo Pro7 22.03.2021](https://innophore.com/media/galileo-pro7-22-03-2021/)
- [Austrian Broadcasting Corporation 28.01.2021](https://innophore.com/media/austrian-broadcasting-corporation-28-01-2021/)

## Categories

- [Print](https://innophore.com/category/print/)
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