What we can find out on a structural bioinformatics level

Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2.

Singh, A., Steinkellner, G., Köchl, K., Gruber. K., Gruber. C.C. Sci Rep 11, 4320 (2021).

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Responding to the ongoing epidemic COVID-19 coronavirus outbreak, the FASTCURE consortium aims to rapidly identify, collect and verify chemical compounds and methods suitable for inhibiting SARS-CoV-2 (formerly known as 2019-nCoV) Mpro protease as a primary target.
Worldwide leading institutions active in bioinformatics, drug-screening, and design supported by major European HPC facilities will be redundantly cross-linked with high-throughput experimental in-vitro and in-vivo validation methods comprising cell culture compound screening, X-ray, and NMR complex determination to continuously evaluate potential compounds.

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